Description

tert-Butyl (R)-(+)-2-Hydroxybutyrate is a high-purity chiral building block and ester derivative of (R)-2-hydroxybutyric acid. This compound is valued for its role as a key intermediate in the asymmetric synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought by research and development chemists and process engineers in fine chemical manufacturing for producing active pharmaceutical ingredients (APIs), chiral ligands, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure APIs, especially in cardiovascular and metabolic disease research.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands, auxiliaries, and catalysts used in stereoselective transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & Industrial Research: A valuable reagent for methodological development in organic synthesis and stereochemistry studies.
• Material Science: Potential monomer or modifier in the synthesis of polymers with specific chiral or functional properties.

Basic Information

Product Name	tert-Butyl (R)-(+)-2-Hydroxybutyrate
CAS No.	206996-51-2
Molecular Formula	C8H16O3
Molecular Weight	160.21 g/mol
Synonyms	(R)-2-Hydroxybutyric Acid tert-Butyl Ester; (R)-(+)-2-Hydroxybutyric Acid tert-Butyl Ester; tert-Butyl (R)-2-hydroxybutanoate; (R)-tert-Butyl 2-hydroxybutyrate; (2R)-2-Hydroxybutanoic Acid 1,1-Dimethylethyl Ester; (R)-HOBu-t-Butyl Ester; (R)-2-Hydroxybutyrate tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (R)-(+)-2-Hydroxybutyrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]	+8.0° to +12.0° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.