Description

Ethyl Trimethylsilyldifluoroacetate is a specialized organosilicon reagent featuring a difluoroacetate ester group protected by a trimethylsilyl moiety. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly for introducing difluoromethyl and related fluorinated groups. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel fluorinated compounds with enhanced biological activity or unique physical properties.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of difluoromethyl-containing active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, where fluorine atoms can improve efficacy and environmental stability.
• Material Science Precursor: Serves as a monomer or modifying agent in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Fluorination Reagent: Acts as a source of the -CF2CO2- unit in nucleophilic and electrophilic fluorination reactions under mild conditions.
• Peptide & Protein Modification: Employed in bioconjugation chemistry to introduce stable, fluorinated labels or probes onto biomolecules.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, Reformatsky-type reactions, and as a precursor to various difluorinated heterocycles and complex molecules.

Basic Information

Item	Detail
Product Name	Ethyl Trimethylsilyldifluoroacetate
CAS No.	205865-67-4
Molecular Formula	C7H14F2O2Si
Molecular Weight	196.27 g/mol
Synonyms	Ethyl 2-(Trimethylsilyl)-2,2-difluoroacetate; (Trimethylsilyl)difluoroacetic Acid Ethyl Ester; 2,2-Difluoro-2-(trimethylsilyl)acetic Acid Ethyl Ester; TMS-difluoroacetate Ethyl Ester; Ethyl (Trimethylsilyl)difluoroacetate; Difluoro(trimethylsilyl)acetate Ethyl Ester; Ethyl α,α-Difluoro-α-(trimethylsilyl)acetate
EINECS	Contact for details

Quality Control

Our Ethyl Trimethylsilyldifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.