Description

1-(Triisopropylsilyloxy)Cyclopropylmethanol is a specialized organosilicon-protected cyclopropane derivative, serving as a versatile chiral building block and protective group reagent in advanced organic synthesis. Its core value lies in enabling complex molecular construction with high stereochemical control, particularly for the synthesis of strained ring systems and natural product analogs. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) with cyclopropane motifs, particularly in antiviral and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the cyclopropane ring enhances biological activity and stability.
• Asymmetric Catalysis & Ligand Design: Serves as a precursor for chiral ligands and catalysts used in enantioselective transformations.
• Advanced Material Monomers: Building block for polymers and specialty materials requiring rigid, strained ring structures to modify thermal and mechanical properties.
• Natural Product Synthesis: Critical intermediate in the total synthesis of complex natural products containing cyclopropane units.
• Protective Group Chemistry: The triisopropylsilyl (TIPS) group provides robust protection for alcohols under a wide range of reaction conditions, allowing for selective deprotection.

Basic Information

Product Name	1-(Triisopropylsilyloxy)Cyclopropylmethanol
CAS No.	205756-60-1
Molecular Formula	C13H28O2Si
Molecular Weight	244.45 g/mol
Synonyms	Cyclopropylmethanol, 1-[(triisopropylsilyl)oxy]-; 1-(Triisopropylsilyloxy)cyclopropanemethanol; 1-Hydroxymethylcyclopropyloxy-triisopropylsilane; (1-Hydroxymethylcyclopropyloxy)triisopropylsilane; TIPS-protected cyclopropanemethanol; 1-[(Triisopropylsilyl)oxy]cyclopropanemethanol; Cyclopropanemethanol, 1-[(triisopropylsilyl)oxy]-; 1-(TIPS-oxy)cyclopropylmethanol
EINECS	Contact for details

Quality Control

Our 1-(Triisopropylsilyloxy)Cyclopropylmethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment. We adhere to cGMP principles for advanced pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.