Description

D-Pyroglutamic Acid tert-Butyl Ester is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound is valued for its role in constructing complex peptide mimetics and pharmaceutical intermediates with precise stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs, protease inhibitors, and other bioactive molecules.
• Peptide Chemistry: Serves as a protected glutamic acid derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Prodrug Development: Used to create tert-butyl ester prodrug forms to enhance the bioavailability and stability of carboxylic acid-containing drug candidates.
• Chemical Biology Research: Employed in the study of enzyme mechanisms and the development of chemical probes.
• Agrochemical Synthesis: A building block for creating chiral active ingredients with specific biological activity.
• Material Science: Potential monomer for the synthesis of specialized polymers with unique properties.

Basic Information

Product Name	D-Pyroglutamic Acid tert-Butyl Ester
CAS No.	205524-46-5
Molecular Formula	C9H15NO3
Molecular Weight	185.22 g/mol
Synonyms	(R)-5-Oxo-2-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; D-(-)-Pyroglutamic acid tert-butyl ester; (R)-1-(tert-Butoxycarbonyl)-2-pyrrolidinone; (R)-tert-Butyl 5-oxopyrrolidine-2-carboxylate; (R)-N-Boc-2-pyrrolidinone; D-Pyroglutamic acid t-butyl ester; (R)-5-Oxopyrrolidine-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our D-Pyroglutamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.