Description

Spiro[2.2]Pentane, 1-Bromo-2-Methylene- (9Ci) is a specialized brominated spirocyclic compound with a highly strained and reactive bicyclopentane core. This unique structure makes it a valuable and versatile building block in advanced organic synthesis, particularly for constructing complex three-dimensional molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications requiring precise molecular engineering.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, due to its ability to impart favorable physicochemical properties.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides, where its spirocyclic framework can contribute to enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Acts as a scaffold for creating novel chiral ligands and organocatalysts used in asymmetric synthesis to produce enantiomerically pure compounds.
• Advanced Materials Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials where its rigid, three-dimensional geometry can influence material properties.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form complex carbon-carbon bonds.
• Academic and R&D Laboratories: A critical reagent for methodological studies in organic chemistry, exploring new reaction pathways involving strained ring systems.

Basic Information

Item	Details
Product Name	Spiro[2.2]Pentane, 1-Bromo-2-Methylene- (9Ci)
CAS No.	205446-86-2
Molecular Formula	C6H7Br
Molecular Weight	159.03 g/mol
Synonyms	1-Bromo-2-methylenespiro[2.2]pentane; 2-Methylene-1-bromospiro[2.2]pentane; 1-Bromo-2-methylidene-spiro[2.2]pentane; Bromomethylenespiropentane; Spiro[2.2]pentane, 1-bromo-2-methylene-; 205446-86-2 (CAS); Bicyclo[1.1.1]pentane, 1-bromo-3-methylene- (related skeleton)
EINECS	Contact for details

Quality Control

Every batch of Spiro[2.2]Pentane, 1-Bromo-2-Methylene- (9Ci) is produced and analyzed under strict quality protocols to ensure consistency and reliability for research and development purposes. Our products undergo rigorous quality testing, including chromatographic purity analysis and structural confirmation, to meet the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Research Grade)
Purity (GC/HPLC)	≥ 98% (Premium Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.