Description

Ethyl 2-Iodo-4-(Trifluoromethyl)Benzoate is a high-value fluorinated aromatic building block, specifically designed for advanced organic synthesis. Its molecular architecture, featuring both an iodine substituent and a trifluoromethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Serves as a precursor for liquid crystals, organic semiconductors, and other advanced functional materials requiring specific fluorinated aromatic cores.
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form biaryl and other complex structures.
• Chemical Synthesis: Employed in nucleophilic substitution and functional group transformation reactions to introduce the benzoate ester moiety into target molecules.

Basic Information

Product Name	Ethyl 2-Iodo-4-(Trifluoromethyl)Benzoate
CAS No.	204981-54-4
Molecular Formula	C10H8F3IO2
Molecular Weight	344.07 g/mol
Synonyms	2-Iodo-4-(trifluoromethyl)benzoic acid ethyl ester; Ethyl 2-iodo-α,α,α-trifluoro-p-toluate; Benzoic acid, 2-iodo-4-(trifluoromethyl)-, ethyl ester; Ethyl 2-iodo-4-trifluoromethylbenzoate; 4-(Trifluoromethyl)-2-iodobenzoic Acid Ethyl Ester; Ethyl α,α,α-trifluoro-2-iodo-p-toluate; p-Toluic acid, α,α,α-trifluoro-2-iodo-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2-Iodo-4-(Trifluoromethyl)Benzoate is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical research and development projects. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.