Description

Boc-1-Aminomethyl-Cyclohexane Carboxylic Acid is a protected amino acid derivative of significant importance in synthetic organic and medicinal chemistry. Its core value lies in serving as a versatile and crucial building block for the synthesis of complex peptides and peptidomimetics, where the Boc (tert-butoxycarbonyl) group provides orthogonal protection for the amine functionality. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries, particularly in the development of new therapeutic agents and bioactive compounds. Its structural features make it a key intermediate for introducing constrained, cyclohexane-based motifs into molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, especially those requiring constrained amino acid analogs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a sterically hindered, cycloalkane-based amino acid residue into peptide chains.
• Peptidomimetic Design: Essential for creating peptidomimetics—molecules that mimic the structure and function of peptides but with enhanced metabolic stability and bioavailability.
• Chemical Biology Research: Employed as a tool compound in research to study protein-protein interactions, enzyme inhibitors, and probe development.
• Combinatorial Chemistry: Serves as a valuable scaffold in libraries for high-throughput screening to discover new lead compounds with therapeutic potential.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex organic molecules for client projects.

Basic Information

Product Name	Boc-1-Aminomethyl-Cyclohexane Carboxylic Acid
CAS No.	204514-23-8
Molecular Formula	C₁₃H₂₃NO₄
Molecular Weight	257.33 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)aminomethyl]cyclohexanecarboxylic Acid; (1-((tert-Butoxycarbonyl)aminomethyl)cyclohexyl)carboxylic Acid; Boc-Amc-OH; Boc-1-Amc-OH; N-Boc-1-Aminomethyl-cyclohexanecarboxylic Acid; N-(tert-Butoxycarbonyl)-1-(aminomethyl)cyclohexanecarboxylic Acid; Cyclohexanecarboxylic acid, 1-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-
EINECS	Contact for details

Quality Control

Our Boc-1-Aminomethyl-Cyclohexane Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity (by IR, NMR), and specific impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under dry conditions to prevent degradation. For long-term storage, consider using a desiccator or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.