Description

Lumefantrine is a synthetic aryl amino alcohol compound that serves as a critical antimalarial agent. It is a key component in artemisinin-based combination therapies (ACTs), which are the first-line treatment for uncomplicated *Plasmodium falciparum* malaria globally. This active pharmaceutical ingredient (API) is essential for manufacturers of finished pharmaceutical products, particularly in the production of combination therapies with artemether. Its importance is underscored by its inclusion on the World Health Organization's Model List of Essential Medicines.

Application

• Pharmaceutical API: Primary use as the active pharmaceutical ingredient in antimalarial combination therapies.
• Fixed-Dose Combination Drugs: Manufacture of co-formulated tablets, most notably in combination with artemether (e.g., Artemether-Lumefantrine).
• Generic Drug Production: Sourcing for generic pharmaceutical companies supplying malaria treatment to global health organizations and national programs.
• Preclinical & Formulation Research: Used in R&D for developing new antimalarial formulations and studying drug resistance mechanisms.
• Reference Standard: Serves as a chemical reference standard in quality control laboratories for drug testing and verification.

Basic Information

Product Name	Lumefantrine
CAS No.	204133-10-8
Molecular Formula	C30H32Cl3NO
Molecular Weight	528.94 g/mol
Synonyms	Benflumetol; 2-Dibutylamino-1-[2,7-dichloro-9-((4-chlorophenyl)methylidene)-9H-fluoren-4-yl]ethanol; 1-[(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]-2-(dibutylamino)ethanol; CGP 56695; Halfan (brand name component); Coartem (brand name component)
EINECS	Contact for details

Quality Control

Our Lumefantrine is manufactured under strict quality management systems. It is produced to meet the rigorous standards required for active pharmaceutical ingredients (APIs), with specifications typically aligned with major pharmacopoeias such as the USP (United States Pharmacopeia) and EP (European Pharmacopoeia). Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F). The container should be kept in a dry, well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.