Description

Ethyl 2,4,5-Trifluoro-3-Iodobenzoate is a high-value, multi-functional aromatic building block characterized by its unique trifluoro and iodo substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced synthetic pathways. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of fluorinated drug candidates, particularly in kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as OLEDs and semiconductors.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings for carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and molecular recognition studies.
• Fluorine Chemistry Research: A valuable tool for academic and industrial research exploring the effects of polyfluorination on molecular properties.

Basic Information

Product Name	Ethyl 2,4,5-Trifluoro-3-Iodobenzoate
CAS No.	203916-66-9
Molecular Formula	C9H6F3IO2
Molecular Weight	322.04 g/mol
Synonyms	Benzoic acid, 2,4,5-trifluoro-3-iodo-, ethyl ester; Ethyl 2,4,5-Trifluoro-3-iodobenzoate; 3-Iodo-2,4,5-trifluorobenzoic Acid Ethyl Ester; 2,4,5-Trifluoro-3-iodobenzoic Acid Ethyl Ester; Ethyl 3-Iodo-2,4,5-trifluorobenzoate; ETIB; Ethyl α,α,α,2,4-Pentafluoro-3-iodobenzoate (incorrect but common misnomer)
EINECS	Contact for details

Quality Control

Our Ethyl 2,4,5-Trifluoro-3-Iodobenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.