Description

6-Boc-6-Aza-Spiro[3.4]Octane-2-Methanol is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and aza-bicyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for constructing complex molecular architectures. It is primarily sought after by pharmaceutical companies and research institutions engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained, three-dimensional spirocyclic structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the synthesis of specialized molecular probes for studying biological pathways and enzyme functions.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability and bioavailability.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	6-Boc-6-Aza-Spiro[3.4]Octane-2-Methanol
CAS No.	203662-48-0
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	tert-Butyl 2-(hydroxymethyl)-2-azaspiro[3.4]octane-6-carboxylate; 2-(Hydroxymethyl)-2-azaspiro[3.4]octane-6-carboxylic Acid tert-Butyl Ester; 6-(tert-Butoxycarbonyl)-6-azaspiro[3.4]octane-2-methanol; 6-Boc-6-azaspiro[3.4]octane-2-methanol; 2-Azaspiro[3.4]octane-2-methanol, 6-[(1,1-dimethylethoxy)carbonyl]-; Boc-Protected 6-Aza-Spiro[3.4]Octane-2-Methanol
EINECS	Contact for details

Quality Control

Our 6-Boc-6-Aza-Spiro[3.4]Octane-2-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.