Description

6-Boc-2-Oxo-6-Aza-Spiro[3.4]Octane CAS NO 203661-71-6 is a high-purity, protected heterocyclic building block featuring a spirocyclic scaffold. This compound is of significant value in medicinal chemistry for the synthesis of novel, three-dimensional molecular architectures, which are crucial for developing new therapeutic agents. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the discovery and production of innovative active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, particularly in programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in fragment-based drug design and lead optimization to introduce constrained, spirocyclic motifs that improve drug-like properties such as metabolic stability and selectivity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or core component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Employed in the creation of specialized molecular tools for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the scalable production of advanced intermediates under cGMP conditions.

Basic Information

Product Name	6-Boc-2-Oxo-6-Aza-Spiro[3.4]Octane
CAS No.	203661-71-6
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	tert-Butyl 2-oxo-6-azaspiro[3.4]octane-6-carboxylate; 6-(tert-Butoxycarbonyl)-6-azaspiro[3.4]octan-2-one; 6-Boc-6-azaspiro[3.4]octan-2-one; 6-Azaspiro[3.4]octan-2-one, 6-[(1,1-dimethylethoxy)carbonyl]-; 6-Boc-2-oxo-6-azaspiro[3.4]octane; 6-Boc-6-aza-spiro[3.4]octane-2-one; 6-Boc-2-oxo-6-aza-spiro[3.4]octane; 6-Boc-2-oxo-6-azaspiro[3.4]octane
EINECS	Contact for details

Quality Control

Our 6-Boc-2-Oxo-6-Aza-Spiro[3.4]Octane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all relevant specifications. We support development and commercial projects with material suitable for research use through to cGMP-grade supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.