Description

Methyl 3-Bromo-5-Chloro-4-Methylbenzoate is a high-purity, multi-functional halogenated benzoate ester serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile aromatic scaffold with orthogonal reactive sites for constructing complex molecules in pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries who require reliable, high-quality intermediates for lead optimization and scale-up.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging its halogenated structure for bioactivity.
• Ligand and Material Science: Serves as a starting material for creating specialized ligands for catalysis and functional monomers for advanced polymers.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and route scouting.
• Academic & Industrial Research: A valuable reagent for exploring new synthetic methodologies and constructing molecular libraries for screening.

Basic Information

Product Name	Methyl 3-Bromo-5-Chloro-4-Methylbenzoate
CAS No.	203573-07-3
Molecular Formula	C9H8BrClO2
Molecular Weight	263.52 g/mol
Synonyms	3-Bromo-5-chloro-4-methylbenzoic acid methyl ester; Methyl 3-bromo-5-chloro-p-toluate; Benzoic acid, 3-bromo-5-chloro-4-methyl-, methyl ester; 4-Methyl-3-bromo-5-chlorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Bromo-5-Chloro-4-Methylbenzoate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the exacting standards required for pharmaceutical and advanced chemical synthesis intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Melting Point	Contact for details
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.