Description

N n-Dibenzyl-D-Serine Methyl Ester is a protected derivative of the non-natural D-serine amino acid, serving as a crucial chiral building block in advanced organic synthesis. This compound is valued for its role in introducing the D-serine moiety into complex molecular architectures while offering orthogonal protection for the amine and carboxylic acid functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of peptides, peptidomimetics, and other bioactive molecules where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for neurological and metabolic targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate D-serine residues, enabling the creation of peptides with enhanced stability or specific biological activity.
• Proteomics & Biochemical Research: Employed as a standard or building block in studying enzyme mechanisms, protein structure, and for the preparation of enzyme inhibitors.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Ligand & Catalyst Development: Utilized in the preparation of chiral ligands for metal catalysis or organocatalysts used in fine chemical manufacturing.

Basic Information

Product Name	N n-Dibenzyl-D-Serine Methyl Ester
CAS No.	202478-34-0
Molecular Formula	C18H21NO3
Molecular Weight	299.36 g/mol
Synonyms	D-Serine, N,N-dibenzyl-, methyl ester; Methyl N,N-dibenzyl-D-serinate; Methyl (R)-2-(dibenzylamino)-3-hydroxypropanoate; (R)-Methyl 2-(dibenzylamino)-3-hydroxypropanoate; N,N-Dibenzyl-D-serine methyl ester; DB-D-Ser-OMe; D-Ser(OBzl2)-OMe; (2R)-2-(Dibenzylamino)-3-hydroxypropanoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of N n-Dibenzyl-D-Serine Methyl Ester is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is sensitive to strong alkali and should be kept away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.