Description

(S)-Pomalidomide CAS NO 202271-89-4 is the S-enantiomer of the potent immunomodulatory and anti-angiogenic agent, pomalidomide. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in the study of structure-activity relationships and enantiomer-specific biological effects. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on oncology and immunology therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a critical chiral reference material for analytical method development and validation in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the research-scale synthesis and development of enantiomerically pure pharmaceutical compounds.
• Mechanistic & Pharmacological Research: Essential for in vitro and in vivo studies to investigate the distinct biological activity, pharmacokinetics, and metabolic pathways of the (S)-enantiomer.
• Process Chemistry & Optimization: Employed in the development and scaling of asymmetric synthesis routes for novel drug candidates.
• Regulatory Submissions: Provides necessary data and materials for regulatory filings requiring characterization of individual enantiomers.

Basic Information

Product Name	(S)-Pomalidomide
CAS No.	202271-89-4
Molecular Formula	C13H11N3O4
Molecular Weight	273.24 g/mol
Synonyms	(S)-4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; (3S)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; (S)-Enantiomer of Pomalidomide; CC-4047 (S-enantiomer); Actimid (S-enantiomer); Pomalyst (S-enantiomer); (S)-3-Aminophthalimidopiperidine-2,6-dione
EINECS	Contact for details

Quality Control

Our (S)-Pomalidomide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.