Description

2',3',5'-Tri-o-Acetyl-5,N3-Dimethyluridine is a key protected nucleoside derivative, specifically a dimethylated and peracetylated analog of uridine. This compound is a critical high-purity building block in the synthesis of modified oligonucleotides and other nucleoside-based pharmaceuticals. It is primarily utilized by research institutions, pharmaceutical R&D labs, and fine chemical manufacturers engaged in developing novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase synthesis of modified RNA and DNA strands for research and therapeutic applications.
• Biochemical Research: Used in studies of nucleic acid structure, function, and metabolism, including enzyme-substrate interactions.
• Prodrug Development: The acetyl groups can be utilized in prodrug strategies to enhance the bioavailability of active nucleoside drugs.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for pharmaceutical manufacturing.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-5,N3-Dimethyluridine
CAS No.	201421-00-3
Molecular Formula	C₁₇H₂₂N₂O₉
Molecular Weight	398.36 g/mol
Synonyms	5,N3-Dimethyl-2',3',5'-tri-O-acetyluridine; 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-5,N3-dimethyl-2,4(1H,3H)-pyrimidinedione; 5,N3-Dimethyl-2',3',5'-tri-O-acetyluridine; 2',3',5'-Tri-O-acetyl-5,N3-dimethyluridine; 5,N(3)-Dimethyl-2',3',5'-tri-O-acetyluridine; 5,N-Dimethyl-2',3',5'-tri-O-acetyluridine
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-5,N3-Dimethyluridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and loss on drying to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.