Description

(1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl-5-Hydroxy-1,3Oxathiolane-2-Carboxylate is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. This compound matters because its complex molecular architecture, featuring a protected hydroxy-oxathiolane moiety, makes it a valuable building block for the development of novel pharmaceuticals and fine chemicals. It is primarily needed by research institutions and industrial manufacturers engaged in the synthesis of nucleoside analogs, antiviral agents, and other bioactive molecules where precise stereochemistry is critical for efficacy.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of antiviral drugs, particularly nucleoside reverse transcriptase inhibitors (NRTIs).
• Fine Chemical Synthesis: Used as a sophisticated building block for constructing complex natural products and other high-value specialty chemicals.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in studies exploring new catalytic methodologies for stereoselective synthesis.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring this specific stereochemical configuration.
• Biochemical Research: Potential use in probing enzyme mechanisms or as a molecular tool in biochemical assays.

Basic Information

Product Name	(1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl-5-Hydroxy-1,3Oxathiolane-2-Carboxylate
CAS No.	200396-19-6
Molecular Formula	C14H24O4S
Molecular Weight	288.41 g/mol
Synonyms	(-)-Menthyl (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylate; L-Menthyl 5-Hydroxy-1,3-oxathiolane-2-carboxylate; (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ester; 5-Hydroxy-1,3-oxathiolane-2-carboxylic acid, (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ester; A key chiral intermediate for Lamivudine analogs.
EINECS	Contact for details

Quality Control

Our (1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl-5-Hydroxy-1,3Oxathiolane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.