Description

Pirenzepine Hydrochloride is a selective muscarinic M1 receptor antagonist, a compound of significant interest in pharmacological research and development. Its primary value lies in its specific receptor affinity, making it a crucial tool for studying cholinergic pathways and gastrointestinal physiology. This high-purity material is essential for researchers and manufacturers in the pharmaceutical and life science sectors, particularly for developing and testing new therapeutic agents.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of anticholinergic and anti-ulcer medications.
• Biochemical Research: Used as a selective probe to study muscarinic acetylcholine receptor subtypes (M1 vs. M2) in neurological and physiological studies.
• Academic & Clinical Studies: Employed in experimental models to investigate gastric acid secretion, peptic ulcer disease mechanisms, and the role of M1 receptors.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and assay calibration in pharmaceutical analysis using HPLC, LC-MS, or titration methods.
• Preclinical Formulations: Utilized in the preparation of dosage forms for animal studies and early-stage pharmacological testing.

Basic Information

Product Name	Pirenzepine Hydrochloride
CAS No.	29868-97-1
Molecular Formula	C19H21N5O2 · HCl
Molecular Weight	387.87 g/mol
Synonyms	Pirenzepine HCl; 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Hydrochloride; Gastrozepin; LS-519; UH-AH 37; (11-[(4-Methylpiperazin-1-yl)acetyl]-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Hydrochloride)
EINECS	Contact for details

Quality Control

Our Pirenzepine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing key parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.