Description

2-Methoxy-3-(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One is a key steroidal intermediate, specifically a protected derivative of estrone. This compound matters for its role as a versatile synthon in the multi-step synthesis of complex pharmaceutical actives, enabling precise chemical modifications. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel steroid-based therapeutics and advanced chemical entities.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of steroidal drugs, including hormone therapies and anti-cancer agents.
• Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and creating novel steroid analogs.
• Fine Chemical Synthesis: Employed in the production of high-value, complex organic molecules requiring specific stereochemistry.
• Process Chemistry: Serves as a starting material or intermediate in optimizing scalable manufacturing processes for active pharmaceutical ingredients (APIs).
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for quality control and analytical method development.

Basic Information

Product Name	2-Methoxy-3-(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One
CAS No.	29825-40-9
Molecular Formula	C22H34O3Si
Molecular Weight	374.60 g/mol
Synonyms	17-Oxo-2-methoxy-3-trimethylsiloxyestra-1,3,5(10)-triene; 2-Methoxy-3-trimethylsiloxyestra-1,3,5(10)-trien-17-one; Estrone 3-trimethylsilyl ether, 2-methyl ether; 3-Trimethylsiloxy-2-methoxyestra-1,3,5(10)-trien-17-one; 2-Methoxy-3-(trimethylsilyloxy)estra-1,3,5(10)-trien-17-one; 2-Methoxyestrone 3-trimethylsilyl ether; O-Trimethylsilyl-2-methoxyestrone
EINECS	Contact for details

Quality Control

Our 2-Methoxy-3-(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.