Description

Silane, (Estra-1,3,5(10)-Trien-3-Yloxy)Trimethyl- is a specialized organosilicon derivative of estra-1,3,5(10)-trien-3-ol, featuring a trimethylsilyl ether protecting group. This compound is of significant value in synthetic organic and medicinal chemistry for its role in protecting sensitive hydroxyl functionalities during complex multi-step synthesis. It is primarily needed by research institutions and pharmaceutical development companies engaged in the synthesis of steroidal compounds, hormone analogs, and other high-value fine chemicals where precise molecular manipulation is required.

Application

• Steroid and Hormone Analog Synthesis: Key intermediate for protecting the 3-hydroxy group of estrane derivatives during chemical modifications at other positions on the steroid nucleus.
• Pharmaceutical Research & Development: Used in the discovery and process development of novel therapeutic agents, particularly in endocrinology and oncology.
• Advanced Organic Synthesis: Serves as a building block or protected intermediate in multi-step synthetic routes for complex natural products and bioactive molecules.
• Chemical Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling in steroid-based APIs.
• Material Science Precursor: Potential use in creating silicon-functionalized organic molecules for hybrid materials or surface modification studies.

Basic Information

Product Name	Silane, (Estra-1,3,5(10)-Trien-3-Yloxy)Trimethyl-
CAS No.	29755-24-6
Molecular Formula	C21H34OSi
Molecular Weight	330.58 g/mol
Synonyms	3-Trimethylsilyloxyestra-1,3,5(10)-triene; Estra-1,3,5(10)-trien-3-ol trimethylsilyl ether; O-Trimethylsilylestrone; Estrone trimethylsilyl ether; Estrone TMS ether; 3-TMS-oxyestra-1,3,5(10)-triene; 3-[(Trimethylsilyl)oxy]estra-1,3,5(10)-triene
EINECS	Contact for details

Quality Control

Our Silane, (Estra-1,3,5(10)-Trien-3-Yloxy)Trimethyl- is produced under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.