Description

Methyl 2,3,5-Tri-o-(4-Chlorobenzoyl)-β-D-Ribofuranoside is a key protected ribofuranoside derivative, serving as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its value lies in providing a strategically protected ribose scaffold, enabling the precise construction of complex nucleoside analogs and other bioactive molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for developing antiviral agents, nucleotide-based therapeutics, and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Antiviral Drug Research: Used in the research and development of modified nucleosides targeting viral polymerases (e.g., for Hepatitis C, HIV).
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase synthesis of modified oligonucleotides and antisense agents.
• Glycosylation Chemistry: Acts as a glycosyl donor or acceptor in stereoselective glycosylation reactions to construct complex carbohydrate structures.
• Fine Chemical Synthesis: Employed as a chiral synthon for the preparation of specialty chemicals, catalysts, and ligands in asymmetric synthesis.
• Agrochemical Development: Utilized in creating novel nucleoside-based fungicides or plant growth regulators.
• Bioconjugation & Probe Development: Useful for labeling biomolecules or creating molecular probes for diagnostic and research applications.

Basic Information

Product Name	Methyl 2,3,5-Tri-o-(4-Chlorobenzoyl)-β-D-Ribofuranoside
CAS No.	29755-00-8
Molecular Formula	C28H23Cl3O8
Molecular Weight	601.84 g/mol
Synonyms	Methyl 2,3,5-Tri-O-(4-chlorobenzoyl)-β-D-ribofuranoside; 1-O-Methyl-2,3,5-tri-O-(4-chlorobenzoyl)-β-D-ribofuranose; β-D-Ribofuranoside, methyl 2,3,5-tris-O-(4-chlorobenzoyl)-; Methyl 2,3,5-Tri-O-(p-chlorobenzoyl)-β-D-ribofuranoside; Protected Methyl Ribofuranoside; 4-Chlorobenzoate Protected Ribose Derivative
EINECS	Contact for details

Quality Control

Our Methyl 2,3,5-Tri-o-(4-Chlorobenzoyl)-β-D-Ribofuranoside is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Products undergo rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.