Description

Trimethyl 3-Bromoorthopropionate is a specialized brominated orthoester building block used in advanced organic synthesis. This compound matters for its role as a versatile reagent in constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for introducing functionalized propionate units under controlled conditions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing bromo-substituted propionate motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialized polymers and functional materials.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions, such as Heck or Suzuki reactions, and in nucleophilic substitution reactions.
• Ligand and Catalyst Development: Useful for synthesizing novel chelating ligands and organometallic catalysts.
• Chemical Research: A valuable tool in academic and industrial laboratories for methodology development and exploring new reaction pathways.

Basic Information

Product Name	Trimethyl 3-Bromoorthopropionate
CAS No.	29328-49-2
Molecular Formula	C6H11BrO3
Molecular Weight	211.06 g/mol
Synonyms	3-Bromo-2,2-dimethoxypropanoic Acid Methyl Ester; Methyl 3-Bromo-2,2-dimethoxypropanoate; Trimethyl Orthopropionate Bromide Derivative; 3-Bromotrimethyl Orthopropionate; Propanoic Acid, 3-Bromo-2,2-dimethoxy-, Methyl Ester; Bromo Trimethyl Orthopropionate
EINECS	Contact for details

Quality Control

Our Trimethyl 3-Bromoorthopropionate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production use. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, ensuring reliability for critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Density	~1.4 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.