Description

(R)-Azidophenylacetic Acid CAS NO 29125-25-5 is a chiral, non-proteinogenic amino acid derivative featuring a reactive azido group, making it a versatile building block in organic synthesis. This compound is particularly valuable for its role in click chemistry applications, enabling efficient and selective bioconjugation. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and diagnostic probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel β-lactam antibiotics and other active pharmaceutical ingredients (APIs).
• Peptide & Protein Modification: Used in site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry for drug delivery systems and antibody-drug conjugates (ADCs).
• Chemical Biology Probes: Serves as a precursor for labeling reagents and activity-based probes to study enzyme function and protein interactions.
• Material Science: Incorporation into polymers and surfaces to introduce biofunctional groups for creating smart biomaterials.
• Agrochemical Research: Utilized as a building block in the research and development of new chiral agrochemicals.

Basic Information

Product Name	(R)-Azidophenylacetic Acid
CAS No.	29125-25-5
Molecular Formula	C8H7N3O2
Molecular Weight	177.16 g/mol
Synonyms	(R)-2-Azido-2-phenylacetic Acid; (R)-α-Azidophenylacetic Acid; D-(-)-α-Azidophenylacetic Acid; (R)-N3PAA; (2R)-2-Azido-2-phenylacetic Acid; (R)-Azidobenzeneacetic Acid; Azido(phenyl)acetic Acid (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (R)-Azidophenylacetic Acid is manufactured under strict quality control protocols to ensure high chemical and chiral purity, critical for sensitive synthetic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, enantiomeric excess (e.e.), and impurity profile. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to light and tendency for oxidation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.