Description

Boc-L-Alanine Methyl Ester CAS NO 28875-17-4 is a protected amino acid derivative widely used as a crucial building block in peptide synthesis. Its primary value lies in the Boc (tert-butoxycarbonyl) protecting group, which shields the amine functionality during coupling reactions and can be removed under mild acidic conditions without affecting the ester group. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity intermediates for the production of peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental monomer for the sequential construction of custom peptide sequences in drug discovery and research.
• Solution-Phase Peptide Synthesis: Used in the synthesis of shorter peptide chains and peptide fragments for various applications.
• Pharmaceutical Intermediate: Serves as a key precursor in the manufacturing of peptide-based therapeutics and diagnostic agents.
• Bioconjugation: Employed to introduce alanine residues or specific functional handles into larger biomolecules like proteins or antibodies.
• Combinatorial Chemistry: Utilized in libraries for high-throughput screening to identify new bioactive compounds.
• Academic & Industrial Research: A standard reagent for studying peptide structure-activity relationships and developing new synthetic methodologies.

Basic Information

Product Name	Boc-L-Alanine Methyl Ester
CAS No.	28875-17-4
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)propanoic acid methyl ester; Methyl (S)-2-((tert-butoxycarbonyl)amino)propanoate; Boc-Ala-OMe; N-(tert-Butoxycarbonyl)-L-alanine methyl ester; N-Boc-L-alanine methyl ester; L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; BOC-L-ALANINE METHYL ESTER; Methyl N-Boc-L-alaninate
EINECS	Contact for details

Quality Control

Our Boc-L-Alanine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for sensitive applications like pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Melting Point	82 - 86 °C
Specific Rotation	-25° to -30° (c=1 in methanol)
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.