Description

Pirenzepine CAS NO 28797-61-7 is a selective muscarinic acetylcholine receptor antagonist belonging to the chemical class of tricyclic compounds. This specificity makes it a valuable pharmacological tool and a key intermediate in the research and development of therapeutic agents targeting gastrointestinal and other smooth muscle disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers. Its well-defined mechanism of action supports critical studies in neuropharmacology and gastroenterology.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of anticholinergic and anti-ulcer medications.
• Biochemical Research: Used as a selective M1 muscarinic receptor antagonist in in vitro and in vivo studies to investigate cholinergic signaling pathways.
• Academic Studies: Employed in university and institutional labs for pharmacological experiments and educational purposes related to receptor-ligand interactions.
• Fine Chemical Synthesis: Acts as a sophisticated building block for the synthesis of novel chemical entities and analogs with potential therapeutic applications.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials or niche pharmaceutical products.

Basic Information

Product Name	Pirenzepine
CAS No.	28797-61-7
Molecular Formula	C19H21N5O2
Molecular Weight	351.41 g/mol
Synonyms	Pirenzepine; Pirenzepine Dihydrochloride (common salt form); Gastrozepin; LS-519; 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; 11-[(4-Methylpiperazin-1-yl)acetyl]-5,6-dihydro-11H-pyrido[2,3-b][1,4]benzodiazepin-11-one
EINECS	249-243-8

Quality Control

Our Pirenzepine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research and pharmaceutical applications. We provide full traceability and support with detailed Certificates of Analysis (COA) for each lot, which include results from HPLC, NMR, and other relevant pharmacopeial tests.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.