Description

Cop-1 is a synthetic copolymer of amino acids, specifically L-alanine, L-lysine, L-glutamic acid, and L-tyrosine, with significant immunological activity. This compound matters for its role as a well-characterized immunomodulator, primarily used to mimic myelin basic protein. It is essential for research and development within the pharmaceutical and biotechnology sectors, particularly for applications in autoimmune disease studies and therapeutic agent development.

Application

• Pharmaceutical Research: Key active pharmaceutical ingredient (API) in the development of therapies for multiple sclerosis (MS).
• Immunological Studies: Used as a model antigen to study T-cell responses and immune tolerance mechanisms.
• Biomaterial Development: Investigated for use in drug delivery systems and vaccine adjuvants due to its polymeric nature.
• Reference Standard: Serves as a critical quality control standard for the production and analysis of glatiramer acetate and related copolymers.
• Preclinical Testing: Employed in animal models to evaluate efficacy and safety profiles of immunomodulatory treatments.

Basic Information

Product Name	Cop-1
CAS No.	28704-27-0
Molecular Formula	(C5H9NO2 · C6H14N2O2 · C5H9NO4 · C9H11NO3)n
Molecular Weight	5,000 - 9,000 Da (Average)
Synonyms	Glatiramer Acetate; Copolymer-1; L-Glutamic acid polymer with L-alanine, L-lysine and L-tyrosine; Poly(L-Alanine, L-Lysine, L-Glutamic Acid, L-Tyrosine); Copaxone® (Brand Name); GA; COP 1
EINECS	Contact for details

Quality Control

Our Cop-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and compliance with pharmaceutical-grade requirements. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as amino acid composition, molecular weight distribution, peptide content, and residual solvents. We adhere to relevant ICH guidelines and can support development aligned with pharmacopeial standards (e.g., USP monographs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference spectrum
Assay (Peptide Content)	≥ 85% (on anhydrous basis)
Amino Acid Composition	L-Alanine, L-Lysine, L-Glutamic Acid, L-Tyrosine in defined molar ratios
Molecular Weight Distribution	Average MW 5,000 - 9,000 Da (by SEC/GPC)
Water Content (KF)	≤ 7.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.