Description

(17R)-3-Methoxy-17-(Trimethylsiloxy)-19-Norpregna-1,3,5(10)-Trien-20-Yne is a high-purity, advanced steroid intermediate featuring a unique norpregnane backbone modified with methoxy and trimethylsiloxy functional groups. This compound is critical for the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and other fine chemicals, offering a versatile and reactive scaffold for further chemical elaboration. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid-based drugs and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new chemical entities targeting hormone receptors and related pathways.
• Fine Chemical Synthesis: Serves as a precursor for the production of complex, high-value specialty chemicals used in advanced material science.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for complex organic molecules in pilot plants and commercial manufacturing.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(17R)-3-Methoxy-17-(Trimethylsiloxy)-19-Norpregna-1,3,5(10)-Trien-20-Yne
CAS No.	28426-34-8
Molecular Formula	C24H34O2Si
Molecular Weight	382.62 g/mol
Synonyms	3-Methoxy-17α-(trimethylsiloxy)-19-norpregna-1,3,5(10)-trien-20-yne; 17α-(Trimethylsilyloxy)-3-methoxy-19-norpregna-1,3,5(10)-trien-20-yne; 3-Methoxy-17-trimethylsiloxy-19-norpregna-1,3,5(10)-trien-20-yne; (17R)-3-Methoxy-17-(trimethylsilyloxy)-19-norpregna-1,3,5(10)-trien-20-yne; 19-Norpregna-1,3,5(10)-trien-20-yne, 3-methoxy-17-(trimethylsiloxy)-, (17R)-; Steroid intermediate 28426-34-8
EINECS	Contact for details

Quality Control

Our (17R)-3-Methoxy-17-(Trimethylsiloxy)-19-Norpregna-1,3,5(10)-Trien-20-Yne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications requiring high standards, including pharmaceutical R&D and cGMP-compliant synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.