Description

6-Amino-Spiro[3.3]heptane-2-carboxylic acid is a high-purity, multifunctional spirocyclic building block of significant interest in advanced organic synthesis. Its unique constrained bicyclic structure, featuring both an amino and a carboxylic acid functional group, makes it a versatile chiral scaffold for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical research and development organizations for the discovery and development of novel therapeutics, including protease inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Peptidomimetics & Constrained Peptide Design: Used to introduce rigid, three-dimensional structural elements into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Chemical Biology & Proteomics: Serves as a specialized scaffold for developing enzyme inhibitors, activity-based probes, and molecular tools to study protein function.
• Ligand Synthesis for Catalysis: Employed in the preparation of sophisticated chiral ligands for asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Agrochemical Research: Used as a precursor in the development of new generation herbicides and pesticides with novel modes of action.
• Material Science: Investigated as a monomer or cross-linker for creating polymers with unique thermal and mechanical properties derived from its spirocyclic core.

Basic Information

Product Name	6-Amino-Spiro[3.3]heptane-2-Carboxylic Acid
CAS No.	28345-67-7
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	6-Azaspiro[3.3]heptane-2-carboxylic acid, 6-amino-; 2-Carboxy-6-azaspiro[3.3]heptane; 6-Amino-2-carboxyspiro[3.3]heptane; 6-Amino-spiro[3.3]heptane-2-carboxylic acid; (1R,2S,5S)-6-Azaspiro[3.3]heptane-2-carboxylic acid (for specific enantiomer); 2-Aminospiro[3.3]heptane-6-carboxylic acid (alternative numbering); Spirocyclic β-amino acid; 6-Azaspiro[3.3]heptane-2-carboxylic acid hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our 6-Amino-Spiro[3.3]heptane-2-carboxylic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and chiral purity analysis to ensure identity, potency, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.