Description

1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Glucopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly functionalized, fully protected derivative of D-glucose, featuring multiple trimethylsilyl (TMS) groups and a phosphoric acid bis(trimethylsilyl) ester moiety. This compound is a critical intermediate in synthetic organic chemistry, particularly valued for its role in the controlled synthesis of complex carbohydrates and nucleoside analogs where selective deprotection is required. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, prodrugs, and advanced glycoconjugates.

Application

• Advanced Carbohydrate Synthesis: Serves as a key protected intermediate for the stepwise construction of oligosaccharides and complex glycan structures.
• Nucleoside & Nucleotide Chemistry: Used in the preparation of modified nucleosides and nucleotide prodrugs, especially those requiring phosphate group protection.
• Pharmaceutical Intermediate: Acts as a building block in the research and development of antiviral and anticancer agents.
• Glycoconjugate Research: Facilitates the synthesis of glycopeptides and glycolipids for biological studies and drug discovery.
• Chemical Biology Probes: Employed in the creation of labeled sugar derivatives for metabolic pathway tracing and enzyme inhibition studies.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) that contain sugar or phosphate components.

Basic Information

Product Name	1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Glucopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	28176-73-0
Molecular Formula	C24H59O9PSi6
Molecular Weight	683.18 g/mol
Synonyms	D-Glucopyranose, 1,2,3,4-tetrakis-O-(trimethylsilyl)-, cyclic 6-(bis(trimethylsilyl) phosphate); 1,2,3,4-Tetra-O-trimethylsilyl-D-glucopyranose 6-(Bis(trimethylsilyl) phosphate); Fully Protected D-Glucose Phosphate TMS Ester; D-Glucose, cyclic 6-(bis(trimethylsilyl) phosphate), 1,2,3,4-tetrakis-O-(trimethylsilyl)-; Hexakis(trimethylsilyl) D-Glucose Phosphate Ester
EINECS	Contact for details

Quality Control

Our production of this high-value synthetic intermediate adheres to strict in-process controls to ensure batch-to-batch consistency and purity. Quality is verified using advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ³¹P), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.