Description

Proline, 5-Methyl-, Ethyl Ester, cis- (8Ci) is a high-purity, non-natural amino acid derivative with the CAS registry number 28168-91-4. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemistry. It is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-quality, enantiomerically pure intermediates for drug discovery, peptide mimetics, and catalyst development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and cardiovascular drug research.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and biological activity for therapeutic candidates.
• Agrochemical Synthesis: Serves as a precursor in the development of chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Asymmetric Catalysis: Employed as a ligand or precursor for chiral catalysts and auxiliaries in enantioselective synthesis.
• Biochemical Research: Utilized as a substrate analog in enzyme inhibition studies and mechanistic investigations.
• Fine Chemical Production: A valuable intermediate for manufacturing specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Item	Details
Product Name	Proline, 5-Methyl-, Ethyl Ester, cis- (8Ci)
CAS No.	28168-91-4
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	cis-5-Methylproline ethyl ester; Ethyl cis-5-methylprolinate; (2S,5S)-5-Methylpyrrolidine-2-carboxylic acid ethyl ester; L-cis-5-Methylproline ethyl ester; 5-Methyl-L-proline ethyl ester; Proline, 5-methyl-, ethyl ester, cis-; Ethyl (2S,5S)-5-methylpyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Proline, 5-Methyl-, Ethyl Ester, cis- (8Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.