Description

Benzyl 2,4-Dioxo-1,3,8-Triazaspiro[4.5]Decane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic triaza structure. This compound is of significant commercial importance as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation drugs, including protease inhibitors and other targeted small-molecule therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those with spirocyclic or constrained heterocyclic cores.
• Protease Inhibitor Research: Used in the research and development of novel protease inhibitors, leveraging its triaza scaffold to interact with enzyme active sites.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology: Employed as a tool compound or a building block for creating chemical probes to study biological pathways.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of proprietary compounds for clients.

Basic Information

Product Name	Benzyl 2,4-Dioxo-1,3,8-Triazaspiro[4.5]Decane-8-Carboxylate
CAS No.	28121-73-5
Molecular Formula	C15H17N3O4
Molecular Weight	303.32 g/mol
Synonyms	8-Benzyloxycarbonyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane; 1,3,8-Triazaspiro[4.5]decane-2,4-dione, 8-(benzyloxycarbonyl)-; Benzyl 1,3,8-triazaspiro[4.5]decane-8-carboxylate-2,4-dione; Cbz-Protected Spirocyclic Triazinedione; Z-Spiro Triazinedione; Spiro[4.5]decane-8-carboxylic acid, 2,4-dioxo-1,3,8-triaza-, benzyl ester
EINECS	Contact for details

Quality Control

Our Benzyl 2,4-Dioxo-1,3,8-Triazaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.