Description

6-(Ethoxycarbonyl)Spiro[3.3]Heptane-2-Carboxylic Acid is a high-purity, multifunctional spirocyclic carboxylic acid derivative serving as a critical advanced pharmaceutical intermediate (API) and a versatile organic synthesis building block. Its unique spiro[3.3]heptane core provides a rigid, three-dimensional structure that is highly valuable for modulating the physicochemical properties of target molecules in drug discovery. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients with improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule drugs, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the spirocyclic structure can enhance biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of novel polymers and functional materials with specific structural properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, sterically defined carboxylic acid derivatives.

Basic Information

Product Name	6-(Ethoxycarbonyl)Spiro[3.3]Heptane-2-Carboxylic Acid
CAS No.	28114-90-1
Molecular Formula	C11H16O4
Molecular Weight	212.24 g/mol
Synonyms	Ethyl 2-Carboxyspiro[3.3]heptane-6-carboxylate; 6-Carbethoxy-2-spiro[3.3]heptanecarboxylic Acid; 2-Carboxyspiro[3.3]heptane-6-carboxylic Acid Ethyl Ester; Spiro[3.3]heptane-2,6-dicarboxylic Acid 6-Ethyl Ester; 6-(Ethoxycarbonyl)spiro[3.3]heptane-2-carboxylic acid; 28114-90-1; Spirocyclic C11 Acid Ester
EINECS	Contact for details

Quality Control

Our 6-(Ethoxycarbonyl)Spiro[3.3]Heptane-2-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay purity and impurity profiles. Our quality commitment ensures the material meets the exacting standards required for GMP and non-GMP pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.