Description

Polyestradiol is a synthetic, polymerized form of estradiol, a potent estrogen hormone. This specialized compound is engineered for controlled-release applications, offering enhanced stability and prolonged activity compared to its monomeric counterpart. It is primarily utilized in advanced pharmaceutical research and development, particularly for hormone replacement therapies and oncology studies targeting estrogen-sensitive pathways.

Application

• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the synthesis of long-acting hormonal therapeutics.
• Controlled-Release Drug Delivery Systems: Engineered for use in implants, microspheres, or other depot formulations requiring sustained estrogen release.
• Oncological Research: Used in preclinical studies to investigate estrogen receptor biology and develop treatments for hormone-dependent cancers.
• Endocrinology Research: A critical tool for studying estrogenic effects, metabolic pathways, and developing novel hormone therapies.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Polyestradiol
CAS No.	28014-46-2
Molecular Formula	(C18H24O2)n
Molecular Weight	Variable (Polymer)
Synonyms	Estradiol Polymer; Poly(estradiol); Polyestradiol Phosphate (related form); Estradiol Polydisperse; NSC-135779; Polymeric Estradiol; Long-Acting Estradiol Polymer; Estradiol Depot Polymer
EINECS	Contact for details

Quality Control

Our Polyestradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and polymer characterization, to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) documenting identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solvent Residue (GC)	Meets ICH guidelines
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.