Description

1-Methyl-L-Proline Methyl Ester is a high-purity, non-natural proline derivative characterized by its chiral, constrained pyrrolidine ring structure. This compound is a critical chiral building block and intermediate in modern organic synthesis, offering significant value in the development of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of peptide mimetics, active pharmaceutical ingredients (APIs), and other fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other peptide-based therapeutics.
• Peptidomimetic Research: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Serves as a chiral auxiliary or catalyst ligand in stereoselective transformations to create enantiomerically pure compounds.
• Agrochemical Development: Employed in the research and synthesis of advanced, chiral active ingredients for crop protection.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals and advanced materials requiring specific stereochemistry.

Basic Information

Product Name	1-Methyl-L-Proline Methyl Ester
CAS No.	27957-91-1
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	L-Proline, 1-methyl-, methyl ester; Methyl 1-methyl-L-prolinate; (S)-1-Methylpyrrolidine-2-carboxylic acid methyl ester; Methyl (2S)-1-methylpyrrolidine-2-carboxylate; 1-Methyl-L-proline methyl ester; 1-Methylproline methyl ester; Methyl 1-methylprolinate
EINECS	Contact for details

Quality Control

Our 1-Methyl-L-Proline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.