Description

n-(Trimethylsilyl)-L-Methionine Trimethylsilyl Ester is a high-purity, silylated derivative of the essential amino acid L-methionine, designed for advanced synthetic applications. This compound is critical for protecting reactive functional groups during complex multi-step organic syntheses, particularly in peptide and pharmaceutical research. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require precise and reliable building blocks for sensitive reactions.

Application

• Peptide Synthesis: Acts as a key protected intermediate for the incorporation of methionine residues in solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and development of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Derivatization Agent: Used in analytical chemistry for the derivatization of amino acids and other compounds containing carboxylic acid or amine groups to enhance volatility for GC or GC-MS analysis.
• Organosilicon Chemistry: Employed as a reagent in the synthesis of silicon-containing organic molecules and materials for specialized applications.
• Bioconjugation: Facilitates the site-specific modification of proteins and biomolecules in research settings.
• Fine Chemical Synthesis: Provides a protected form of methionine for the synthesis of complex natural products, flavors, and fragrances.

Basic Information

Product Name	n-(Trimethylsilyl)-L-Methionine Trimethylsilyl Ester
CAS No.	27844-10-6
Molecular Formula	C11H25NO2SSi2
Molecular Weight	291.55 g/mol
Synonyms	L-Methionine, N-(trimethylsilyl)-, trimethylsilyl ester; N,O-Bis(trimethylsilyl)-L-methionine; N-(Trimethylsilyl)methionine trimethylsilyl ester; Silylated L-Methionine; TMS-Methionine; Bis(trimethylsilyl)methionine; Methionine bis(trimethylsilyl) derivative; (2S)-2-[(Trimethylsilyl)amino]-4-(methylsulfanyl)butanoic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-L-Methionine Trimethylsilyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with internal quality standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.