Description

n-Trimethylsilyl-L-Alanine Trimethylsilyl Ester is a highly specialized organosilicon derivative of the amino acid L-alanine, featuring dual trimethylsilyl (TMS) protecting groups. This compound is a critical reagent in advanced organic synthesis, primarily valued for its role in protecting sensitive functional groups and facilitating complex peptide and chiral molecule construction. It is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, moisture-sensitive intermediates for sophisticated synthetic routes.

Application

• Peptide Synthesis Intermediate: Serves as a key protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Chiral Building Block: Utilized in the asymmetric synthesis of pharmaceuticals and fine chemicals, leveraging the chirality of the L-alanine backbone.
• Gas Chromatography Derivatization Agent: Used to silylate amino acids and other polar compounds for analysis by GC and GC-MS, improving volatility and thermal stability.
• Protecting Group Chemistry: The trimethylsilyl groups effectively protect carboxylic acid and amine functionalities during multi-step synthetic sequences.
• Advanced Material Research: Acts as a precursor or modifying agent in the development of silicon-containing polymers and hybrid organic-inorganic materials.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	n-Trimethylsilyl-L-Alanine Trimethylsilyl Ester
CAS No.	27844-07-1
Molecular Formula	C9H23NO2Si2
Molecular Weight	233.46 g/mol
Synonyms	L-Alanine, N-(trimethylsilyl)-, trimethylsilyl ester; N,O-Bis(trimethylsilyl)-L-alanine; N-Trimethylsilyl-L-alanine trimethylsilyl ester; N-TMS-L-alanine TMS ester; (S)-2-((Trimethylsilyl)amino)propanoic acid trimethylsilyl ester; Bis(trimethylsilyl)-L-alaninate; Alanine, N-trimethylsilyl-, trimethylsilyl ester, L-
EINECS	Contact for details

Quality Control

Our n-Trimethylsilyl-L-Alanine Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the stringent requirements for research and process chemistry. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and highly volatile nature, this product must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.