Description

m-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester is a specialized organosilicon intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a versatile building block, enabling the introduction of the trimethylsiloxy-protected benzyl moiety into complex molecular architectures. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug molecules, particularly those requiring protected phenolic or benzyl alcohol functionalities.
• Peptide Mimetics & Modifications: Used to incorporate silicon-containing side chains into peptide backbones, potentially altering their stability, lipophilicity, and biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing silicon-based derivatives used in electronic display technologies and organic light-emitting diodes.
• Polymer & Resin Modification: Employed to functionalize polymers, imparting specific properties like altered surface energy, thermal stability, or reactivity.
• Agrochemical Synthesis: Utilized in the development of novel pesticides and herbicides where the silicon group can influence bioavailability and environmental persistence.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl systems.
• Protecting Group Chemistry: The trimethylsiloxy group can act as a protecting group for phenols during complex synthetic sequences.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory chemistry in academic and industrial R&D laboratories.

Basic Information

Item	Detail
Product Name	m-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester
CAS No.	27798-61-4
Molecular Formula	C₁₂H₁₈O₃Si
Molecular Weight	238.36 g/mol
Synonyms	Methyl 3-(Trimethylsiloxy)phenylacetate; Methyl (3-Trimethylsilyloxyphenyl)acetate; 3-(Trimethylsiloxy)benzeneacetic Acid Methyl Ester; m-(Trimethylsilyloxy)benzeneacetic Acid Methyl Ester; (3-Methoxyphenyl)acetic Acid Trimethylsilyl Ester (common misnomer); Methyl 2-[3-(Trimethylsilyloxy)phenyl]acetate; TMS-protected Methyl 3-Hydroxyphenylacetate; 27798-61-4 (CAS Index Name)
EINECS	Contact for details

Quality Control

Our production of m-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against established internal specifications using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.