Description

4-(Trimethylsilyl)Butanoic Acid Methyl Ester is a versatile organosilicon compound that serves as a valuable building block and protecting group reagent in advanced organic synthesis. Its primary value lies in its ability to introduce silyl-protected carboxylic acid functionality, enabling complex multi-step reactions with high selectivity and yield. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries who require reliable, high-purity intermediates for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key synthon in the synthesis of complex drug candidates, particularly those requiring silyl-protected carboxylate groups for selective reactions.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the trimethylsilyl group acts as a temporary protecting moiety.
• Peptide Chemistry: Employed as a reagent for the protection of carboxylic acids during solid-phase and solution-phase peptide synthesis.
• Material Science Research: Serves as a precursor for modifying surface properties or creating silicon-containing polymers and hybrid materials.
• Organic Synthesis Reagent: A versatile building block for constructing carbon-silicon bonds in complex molecule assembly, including natural product synthesis.
• Cross-Coupling Reactions: Potential substrate in palladium-catalyzed cross-coupling reactions for creating new carbon-carbon bonds.

Basic Information

Product Name	4-(Trimethylsilyl)Butanoic Acid Methyl Ester
CAS No.	27798-48-7
Molecular Formula	C8H18O2Si
Molecular Weight	174.31 g/mol
Synonyms	Methyl 4-(Trimethylsilyl)butanoate; Methyl 4-(Trimethylsilyl)butyrate; 4-(Trimethylsilyl)butyric Acid Methyl Ester; Butanoic acid, 4-(trimethylsilyl)-, methyl ester; NSC 163081; Methyl (4-Trimethylsilyl)butanoate; 4-Trimethylsilylbutyric Acid Methyl Ester; Methyl 4-Trimethylsilylbutyrate
EINECS	Contact for details

Quality Control

Our production of 4-(Trimethylsilyl)Butanoic Acid Methyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot is characterized using advanced analytical techniques including GC, HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent exposure to atmospheric moisture, which can lead to hydrolysis. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.420 - 1.430
Density (g/mL at 20°C)	0.88 - 0.92

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.