Description

4,α-Bis[(Trimethylsilyl)Oxy]Benzenepropionic Acid Trimethylsilyl Ester is a specialized organosilicon compound primarily used as a key synthetic intermediate and protecting group reagent. Its value lies in its ability to protect reactive hydroxyl groups during complex multi-step organic syntheses, particularly in the production of sensitive pharmaceutical compounds. This high-purity intermediate is essential for R&D chemists and process development scientists working in advanced pharmaceutical, agrochemical, and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug molecules, especially those requiring protection of phenolic or carboxylic acid functionalities.
• Peptide Synthesis: Used as a protecting group reagent for tyrosine and other amino acid side chains during solid-phase and solution-phase peptide synthesis.
• Agrochemical Production: Serves as an intermediate in the manufacture of advanced pesticides and herbicides where selective protection is required.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products, flavors, fragrances, and specialty materials.
• Material Science Research: Used in the development of novel silicon-containing polymers and hybrid organic-inorganic materials.
• Process Chemistry: Valued in scale-up and pilot plant operations for its stability and predictable reactivity under various conditions.

Basic Information

Product Name	4,α-Bis[(Trimethylsilyl)Oxy]Benzenepropionic Acid Trimethylsilyl Ester
CAS No.	27750-67-0
Molecular Formula	C18H34O4Si3
Molecular Weight	398.71 g/mol
Synonyms	Benzenepropanoic acid, 4-[bis[(trimethylsilyl)oxy]phenyl]-, trimethylsilyl ester; 3-(4-Bis(trimethylsiloxy)phenyl)propionic acid trimethylsilyl ester; TMS-protected 3-(4-dihydroxyphenyl)propionic acid; Trimethylsilyl 3-[4-[bis(trimethylsilyl)oxy]phenyl]propanoate; 4,α-Di-O-trimethylsilyl-3-(4-hydroxyphenyl)propionic acid TMS ester
EINECS	Contact for details

Quality Control

Our 4,α-Bis[(Trimethylsilyl)Oxy]Benzenepropionic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical and advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.