Description

(3-Methoxyphenyl)Acetic Acid Trimethylsilyl Ester is a versatile organosilicon reagent used as a key protected intermediate in advanced organic synthesis. Its primary value lies in providing a silyl-protected carboxylic acid moiety, which is crucial for multi-step synthetic sequences requiring selective deprotection. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: Serves as a protected synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing substituted phenylacetic acid derivatives.
• Peptide Mimetics Research: Used in the preparation of non-peptidic scaffolds and bioisosteres where the trimethylsilyl ester group offers temporary protection.
• Agrochemical Synthesis: Acts as a building block for developing novel herbicides, fungicides, and plant growth regulators.
• Liquid Crystal & OLED Material Precursor: Employed in the synthesis of advanced organic electronic materials requiring specific methoxy-substituted aromatic cores.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed reactions, such as Suzuki-Miyaura or Heck couplings, for constructing complex biaryl systems.
• Asymmetric Synthesis: Utilized as a chiral pool derivative or resolving agent in the production of enantiomerically pure compounds.
• Fragrance & Flavor Chemistry: Intermediate for synthesizing specific aromatic compounds used in high-value fragrance formulations.
• Academic & Process R&D: A valuable reagent for methodological development and scaling new synthetic routes in laboratory settings.

Basic Information

Item	Detail
Product Name	(3-Methoxyphenyl)Acetic Acid Trimethylsilyl Ester
CAS No.	27750-49-8
Molecular Formula	C12H18O3Si
Molecular Weight	238.36 g/mol
Synonyms	2-(3-Methoxyphenyl)acetic acid trimethylsilyl ester; Trimethylsilyl 2-(3-methoxyphenyl)acetate; (3-Methoxyphenyl)acetic acid TMS ester; m-Methoxyphenylacetic acid trimethylsilyl ester; TMS ester of 3-methoxyphenylacetic acid; [3-(Trimethylsilyloxycarbonylmethyl)phenyl] methyl ether; Silylating reagent CAS 27750-49-8
EINECS	Contact for details

Quality Control

Our (3-Methoxyphenyl)Acetic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and GC for residual solvents, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain purity. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.