Description

Trimethylsilyl Trifluoromethanesulfonate is a highly reactive organosilicon reagent and a powerful silylating agent. Its primary value lies in its exceptional ability to introduce the trimethylsilyl (TMS) protecting group under mild conditions, making it indispensable for complex synthetic sequences. This compound is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the protection of alcohols, phenols, and carboxylic acids, and as a catalyst in various organic transformations.

Application

• Pharmaceutical Synthesis: Key reagent for the protection of sensitive functional groups (e.g., hydroxyl, carboxyl) during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides where selective protection and deprotection strategies are required.
• Polymer & Material Science: Employed as a catalyst or initiator in the synthesis of specialized silicones, siloxanes, and other silicon-containing polymers.
• Peptide Chemistry: Facilitates the silylation of amino acids to prevent unwanted side reactions during peptide coupling.
• Natural Product Synthesis: Enables the manipulation of complex, polyfunctional molecules like steroids and sugars by protecting specific sites.
• Analytical Chemistry: Used as a derivatization agent to enhance the volatility and detectability of compounds in Gas Chromatography (GC) and Mass Spectrometry (MS).

Basic Information

Product Name	Trimethylsilyl Trifluoromethanesulfonate
CAS No.	27607-77-8
Molecular Formula	C4H9F3O3SSi
Molecular Weight	222.26 g/mol
Synonyms	Trimethylsilyl Triflate; TMSOTf; Trifluoromethanesulfonic Acid Trimethylsilyl Ester; Trimethylsilyl Trifluoromethanesulphonate; (Trimethylsilyl) Triflate; Silylating Agent T 1250; Methylsilane, Trifluoro(oxomethanesulfonato-O)-
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Trifluoromethanesulfonate is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including assay by GC or titration and impurity profiling. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and a strong acid/organic solvent; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.24 g/mL
Refractive Index (n20D)	~1.360

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.