Description

3-Phenylglycidic Acid tert-Butyl Ester is a high-value chiral epoxide and ester derivative that serves as a critical synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for its utility in stereoselective synthesis and as a key building block for β-blockers and other chiral therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of β-adrenergic blocking agents (β-blockers) and other cardiovascular drugs.
• Asymmetric Synthesis: Utilized as a building block for introducing the phenylglycidyl moiety in stereocontrolled chemical reactions.
• Fine Chemical Production: Serves as a precursor in the manufacture of complex organic molecules for agrochemicals and specialty materials.
• Chemical Research & Development: Employed in academic and industrial R&D for developing new synthetic methodologies and novel chemical entities.
• Chiral Auxiliary/Resolving Agent: Can be used in the preparation or separation of enantiomerically pure compounds.

Basic Information

Product Name	3-Phenylglycidic Acid tert-Butyl Ester
CAS No.	27593-40-4
Molecular Formula	C₁₃H₁₆O₃
Molecular Weight	220.27 g/mol
Synonyms	tert-Butyl 3-Phenylglycidate; 2-Oxiranecarboxylic acid, 3-phenyl-, 1,1-dimethylethyl ester; Glycidic acid, 3-phenyl-, tert-butyl ester; (2R,3S)-3-Phenylglycidic Acid tert-Butyl Ester; (2S,3R)-3-Phenylglycidic Acid tert-Butyl Ester; Phenylglycidic Acid tert-Butyl Ester; TBPE
EINECS	Contact for details

Quality Control

Our 3-Phenylglycidic Acid tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (Specific enantiomer available)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.