Description

Glycine Tert Butyl Ester Hydrochloride is a protected amino acid derivative widely used as a key building block in organic synthesis. This compound is essential for researchers and manufacturers requiring a stable, reactive intermediate for constructing complex peptide and small molecule structures. It is particularly valuable for the pharmaceutical, agrochemical, and biotechnology industries, where precise molecular assembly is critical for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of peptide-based drugs, active pharmaceutical ingredients (APIs), and novel therapeutic candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected glycine derivative to prevent unwanted side reactions.
• Agrochemical Research: Serves as an intermediate in the development of herbicides, fungicides, and other crop protection agents.
• Bioconjugation Chemistry: Employed in the modification of proteins, antibodies, and other biomolecules for diagnostic and therapeutic applications.
• Chemical Biology Probes: Utilized in the creation of labeled amino acids and molecular probes for studying biological processes.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing custom fine chemicals and specialized intermediates.

Basic Information

Product Name	Glycine Tert Butyl Ester Hydrochloride
CAS No.	27532-96-3
Molecular Formula	C6H13NO2·HCl
Molecular Weight	167.63 g/mol (Free base: 131.17 g/mol)
Synonyms	Glycine tert-butyl ester hydrochloride; H-Gly-OtBu·HCl; 2-((tert-Butoxycarbonyl)amino)acetic acid hydrochloride; N-(tert-Butoxycarbonyl)glycine hydrochloride; Boc-Gly-OH·HCl; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride; tert-Butyl glycinate hydrochloride; 2-(tert-Butoxycarbonylamino)acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our Glycine Tert Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	~155-160°C (dec.)
Loss on Drying	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.