Description

2-O,3-O,5-O,6-O,7-o-Pentakis(Trimethylsilyl)-D-Glycero-L-Manno-Heptonic Acid 1,4-Lactone is a highly functionalized, fully protected carbohydrate derivative. This compound is a critical advanced intermediate in the synthesis of complex oligosaccharides and glycoconjugates, offering precise control over stereochemistry and regiochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in carbohydrate chemistry, medicinal chemistry, and the development of novel therapeutics and diagnostics.

Application

• Advanced Glycosylation Intermediate: Serves as a key building block for the solid-phase and solution-phase synthesis of complex oligosaccharides and glycans.
• Medicinal Chemistry Research: Used in the development of carbohydrate-based drugs, including glycomimetics, antiviral agents, and vaccine adjuvants.
• Glycoconjugate Synthesis: Essential for creating glycoproteins, glycolipids, and other biologically active conjugates for biochemical studies.
• Chemical Biology Probes: Acts as a precursor for labeled sugars used to study glycosylation pathways and carbohydrate-protein interactions.
• Chiral Pool Synthesis: Provides a source of chiral complexity for the asymmetric synthesis of non-carbohydrate natural products.
• Process Development: Employed in scaling up synthetic routes for carbohydrate-active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-O,3-O,5-O,6-O,7-o-Pentakis(Trimethylsilyl)-D-Glycero-L-Manno-Heptonic Acid 1,4-Lactone
CAS No.	27531-31-3
Molecular Formula	C28H62O7Si5
Molecular Weight	659.27 g/mol
Synonyms	Pentakis-O-(trimethylsilyl)-D-glycero-L-manno-heptono-1,4-lactone; D-glycero-L-manno-Heptonic acid, 2,3,5,6,7-pentakis-O-(trimethylsilyl)-, 1,4-lactone; Fully TMS-protected heptono-1,4-lactone; 1,4-Lactone of 2,3,5,6,7-penta-O-trimethylsilyl-D-glycero-L-manno-heptonic acid; Protected heptose lactone; TMS-protected sugar lactone; Carbohydrate protecting group intermediate.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing specific results for each parameter are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.