Description

6-α-Hydroxy Ethinylestradiol is a key pharmaceutical intermediate and metabolite of the synthetic estrogen ethinylestradiol. This compound is of significant importance for research and development in the fields of endocrinology and steroid chemistry. It serves as a critical reference standard and building block for analytical laboratories, academic researchers, and pharmaceutical manufacturers focused on hormone-related therapies and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of ethinylestradiol and its metabolites in analytical methods.
• Metabolic Pathway Research: Essential for studying the biotransformation and pharmacokinetics of synthetic estrogens in preclinical and clinical research.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a sophisticated intermediate in the multi-step synthesis of novel steroidal drugs and hormone analogs.
• Analytical Method Development: Critical for developing and validating HPLC, LC-MS, and GC-MS assays in bioanalytical and quality control laboratories.
• Academic & Institutional Research: Used in university and research institute labs for fundamental studies in steroid biochemistry and endocrinology.
• Impurity Profiling: Employed to identify and control process-related impurities and degradation products in ethinylestradiol-based drug formulations.

Basic Information

Product Name	6-α-Hydroxy Ethinylestradiol
CAS No.	27521-34-2
Molecular Formula	C20H24O3
Molecular Weight	312.41 g/mol
Synonyms	6α-Hydroxyethinylestradiol; 17α-Ethynyl-6α,17β-estradiol; 17α-Ethynyl-6α-hydroxyestra-1,3,5(10)-triene-3,17β-diol; 6α-Hydroxy-17α-ethynylestradiol; 6α-Hydroxy-19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17β-diol; Ethinylestradiol 6α-Hydroxy Metabolite
EINECS	Contact for details

Quality Control

Our 6-α-Hydroxy Ethinylestradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment. For long-term storage, consider desiccants or inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.