Description

1-[3-(Triethylsilyl)-2-Propynyl]Piperidine is a specialized organosilicon building block featuring a piperidine moiety linked to a triethylsilyl-protected alkyne. This unique structure makes it a valuable intermediate in advanced organic synthesis, particularly for constructing complex molecules with specific steric and electronic properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the creation of novel pesticides and herbicides, where the piperidine and silyl alkyne groups can contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Acts as a precursor for sophisticated ligands in asymmetric catalysis or as a functional handle in organometallic chemistry.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as molecular wires or components for organic electronics, due to its conjugated alkyne system.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	1-[3-(Triethylsilyl)-2-Propynyl]Piperidine
CAS No.	27001-73-6
Molecular Formula	C14H27NSi
Molecular Weight	237.46 g/mol
Synonyms	1-[(Triethylsilyl)ethynyl]methylpiperidine; 1-(3-(Triethylsilyl)prop-2-yn-1-yl)piperidine; 3-(Piperidin-1-yl)-1-(triethylsilyl)prop-1-yne; (3-Piperidin-1-ylprop-1-yn-1-yl)triethylsilane; TES-protected propargyl piperidine; Triethyl((3-(piperidin-1-yl)prop-1-yn-1-yl))silane
EINECS	Contact for details

Quality Control

Every batch of 1-[3-(Triethylsilyl)-2-Propynyl]Piperidine undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by GC or HPLC), identity confirmation (by IR, NMR), and other relevant parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.