Description

Methyl 3-(Trimethylsilyloxy)Crotonate, Mixture Of Cis And Trans, 90 CAS NO 26767-00-0 is a versatile organosilicon reagent featuring a silyl enol ether functional group. This compound is a valuable synthetic building block, prized for its role as a nucleophile in aldol and Michael addition reactions under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for β-lactam antibiotics and other complex molecules.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its reactivity to construct specific carbon frameworks.
• Fine Chemical Production: Serves as a crucial reagent for the manufacture of specialty chemicals, flavors, and fragrances.
• Polymer & Material Science: Employed in the development of novel polymers and silicone-based materials with tailored properties.
• Academic & R&D: A fundamental tool in organic chemistry laboratories for methodological development and exploratory synthesis.
• Cross-Coupling Reactions: Acts as a coupling partner in various metal-catalyzed reactions to form new carbon-carbon bonds.

Basic Information

Product Name	Methyl 3-(Trimethylsilyloxy)Crotonate, Mixture Of Cis And Trans, 90
CAS No.	26767-00-0
Molecular Formula	C8H16O3Si
Molecular Weight	188.30 g/mol
Synonyms	Methyl 3-(trimethylsilyloxy)-2-butenoate; Methyl 3-(trimethylsiloxy)crotonate; 2-Butenoic acid, 3-(trimethylsilyloxy)-, methyl ester; Methyl β-(trimethylsiloxy)crotonate; Trimethylsilyl methyl acetoacetate; TMS Methyl acetoacetate; Methyl (E/Z)-3-(trimethylsilyloxy)but-2-enoate; Silyl ketene acetal derivative
EINECS	Contact for details

Quality Control

Our Methyl 3-(Trimethylsilyloxy)Crotonate is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity (typically ≥90%), and isomer ratio consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 90% (Mixture of isomers)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.