Description

Ethyl 3-Methoxy-4,4,4-Trifluoro-2-Butenoate is a high-value fluorinated building block and intermediate in organic synthesis. Its structure, featuring a reactive α,β-unsaturated ester moiety and a trifluoromethyl group, makes it a versatile precursor for introducing fluorine into complex molecules, which is critical for modulating the physical, chemical, and biological properties of target compounds. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Advanced Material Precursor: Serves as a monomer or intermediate for fluorinated polymers, liquid crystals, and specialty coatings with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Employed in Michael additions, cycloadditions, and other C-C bond-forming reactions to construct complex, fluorinated heterocycles and aliphatic chains.
• Fluorine Chemistry Research: A valuable tool in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new fluorination methodologies.

Basic Information

Product Name	Ethyl 3-Methoxy-4,4,4-Trifluoro-2-Butenoate
CAS No.	26717-84-0
Molecular Formula	C7H9F3O3
Molecular Weight	198.14 g/mol
Synonyms	Ethyl 3-Methoxy-4,4,4-trifluorobut-2-enoate; 4,4,4-Trifluoro-3-methoxy-2-butenoic Acid Ethyl Ester; 2-Butenoic acid, 4,4,4-trifluoro-3-methoxy-, ethyl ester; 3-Methoxy-4,4,4-trifluorocrotonic Acid Ethyl Ester; Ethyl 3-Methoxy-4,4,4-Trifluorocrotonate; TFMBE; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our Ethyl 3-Methoxy-4,4,4-Trifluoro-2-Butenoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity, consistency, and traceability. Standard quality parameters include assay (by GC/HPLC), identity confirmation (IR, NMR), and control of key impurities. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its properties as a fluoride/strong alkali and highly volatile compound, ensure containers are kept tightly sealed to prevent moisture ingress and evaporation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.