Description

Calcium N5-Methyltetrahydrofolate is the stable, bioavailable calcium salt of the active form of folate (vitamin B9). This compound is critical for its role in one-carbon metabolism, serving as a primary methyl donor for numerous biochemical processes. It is essential for manufacturers in the pharmaceutical, nutraceutical, and clinical nutrition sectors seeking a reliable source of metabolically active folate for high-quality formulations.

Application

• Pharmaceutical Active Ingredient (API): Core component in prescription medications for treating folate deficiency and related metabolic disorders.
• Dietary Supplement Formulation: Key ingredient in premium multivitamins, prenatal vitamins, and standalone folate supplements, especially those targeting individuals with the MTHFR gene polymorphism.
• Medical & Clinical Nutrition: Used in enteral and parenteral nutrition products, meal replacements, and therapeutic foods designed for patients with specific metabolic needs.
• Food Fortification: Employed in the fortification of staple foods and beverages to enhance nutritional value with a highly bioavailable form of folate.
• Research & Diagnostic Reagents: Serves as a standard or reagent in biochemical research, clinical diagnostics, and enzymatic studies related to folate metabolism.

Basic Information

Product Name	Calcium N5-Methyltetrahydrofolate
CAS No.	26560-38-3
Molecular Formula	C20H23CaN7O6
Molecular Weight	497.53 g/mol
Synonyms	L-Methylfolate Calcium; (6S)-5-Methyltetrahydrofolic Acid Calcium Salt; Metafolin® (Brand Name); 5-MTHF Calcium; Levomefolic Acid Calcium Salt; (6S)-5-MTHF-Ca; NSC 139490; Calcium (6S)-5-methyl-5,6,7,8-tetrahydrofolate
EINECS	Contact for details

Quality Control

Our Calcium N5-Methyltetrahydrofolate is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmaceutical-grade expectations. Comprehensive Certificates of Analysis (COA) documenting purity (by HPLC), enantiomeric purity, residual solvents, and heavy metals are provided to guarantee supply reliability and regulatory compliance for your applications.

Storage

Preserve in a tightly closed container, protected from light. Store unopened containers at 2-8°C (refrigerated) or as specified on the label. For long-term storage under inert atmosphere (nitrogen or argon) is recommended to minimize oxidation. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Enantiomeric Purity	≥ 98.0% (6S)-isomer
Water Content (KF)	≤ 8.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.