Description

Diphenylphosphoryl Azide (DPPA) is a versatile and highly reactive organophosphorus reagent primarily used as a coupling agent and azide transfer source in organic synthesis. Its core value proposition lies in enabling efficient, high-yield transformations critical for constructing complex molecules, particularly under mild conditions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries, where it facilitates key reactions like the Curtius rearrangement and peptide coupling.

Application

• Peptide Synthesis: Employed as a coupling reagent for the formation of peptide bonds, especially in solid-phase peptide synthesis (SPPS).
• Curtius Rearrangement: A key reagent for converting carboxylic acids to isocyanates, which are valuable intermediates for amines, urethanes, and ureas.
• Azide Transfer Reactions: Used to introduce azide functional groups into organic molecules for subsequent "click chemistry" or reduction to amines.
• Nucleic Acid Chemistry: Finds application in the synthesis of modified nucleotides and oligonucleotides.
• Pharmaceutical Intermediate Manufacturing: Critical for the synthesis of active pharmaceutical ingredients (APIs) containing carbamate or urea linkages.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require specific amine or isocyanate intermediates.
• Polymer Chemistry: Serves as a monomer or modifying agent for creating polymers with specific functional groups like azides or isocyanates.
• Material Science Research: Utilized in surface functionalization and the creation of advanced materials via azide-alkyne cycloaddition.

Basic Information

Product Name	Diphenylphosphoryl Azide
CAS No.	26386-88-9
Molecular Formula	C12H10N3OP
Molecular Weight	243.20 g/mol
Synonyms	DPPA; Diphenylphosphorazidate; Azidodiphenylphosphine Oxide; Phosphorazidic Acid, Diphenyl Ester; (Azidodiphenylphosphoryl)oxidane; NSC 189875; NSC 622366; Diphenylphosphinic Azide
EINECS	247-668-7

Quality Control

Our Diphenylphosphoryl Azide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maintain stability and extend shelf life. Keep away from heat, sparks, and open flame. Due to its reactivity as a strong acid/organic solvent, store separately from bases, oxidizing agents, and moisture-sensitive materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.550 - 1.560
Density (20°C)	1.28 - 1.32 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.