Description

Trimethylsilyl 2-Iodoethyl Ether is a versatile organosilicon reagent featuring a reactive iodoethyl group protected by a trimethylsilyl (TMS) ether. This compound matters for its dual functionality, serving as a valuable synthon for the controlled introduction of the 2-iodoethyl moiety in complex molecule synthesis under mild conditions. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for constructing carbon-carbon bonds and functionalizing molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing ethylene-linked functional groups.
• Agrochemical Synthesis: Used in the preparation of herbicides, fungicides, and plant growth regulators requiring specific alkyl-iodide linkages.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent in the development of specialty silicones and advanced polymeric materials.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Heck, Negishi) and nucleophilic substitution reactions.
• Protecting Group Strategy: The TMS ether group can act as a temporary protecting group for alcohols, which can be cleaved selectively.
• Labeling & Probe Development: Useful in radiochemistry for iodine-125 labeling or in creating molecular probes for biochemical studies.

Basic Information

Product Name	Trimethylsilyl 2-Iodoethyl Ether
CAS No.	26305-99-7
Molecular Formula	C5H13IOSi
Molecular Weight	244.15 g/mol
Synonyms	2-(Trimethylsilyloxy)ethyl Iodide; (2-Iodoethoxy)trimethylsilane; 2-Iodoethyl Trimethylsilyl Ether; 1-Iodo-2-(trimethylsilyloxy)ethane; TMS-2-Iodoethyl Ether; Trimethyl(2-iodoethoxy)silane; β-Iodoethyl Trimethylsilyl Ether; [(2-Iodoethoxy)methyl]dimethylsilane (alternative)
EINECS	Contact for details

Quality Control

Our Trimethylsilyl 2-Iodoethyl Ether is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.